Tuesday, 22 October 2013

Typical immunohistochemistry results

Immunohistochemical studies play an important role for the pathologist in differentiating malignant mesothelioma from neoplastic mimics. There are numerous tests and panels available. No single test is perfect for distinguishing mesothelioma from carcinoma or even benign versus malignant. Currently, there is no FDA approved immunohistochemistry assay for the diagnosis of mesothelioma so different cancer centers use different panels.
Typical immunohistochemistry results
EMA (epithelial membrane antigen) in a membranous distributionCEA (carcinoembryonic antigen)
WT1 (Wilms' tumour 1)B72.3
Calretinin[5]MOC-3 1
Cytokeratin 5/6[5]Ber-EP4
HBME-1 (human mesothelial cell 1)TTF-1 (thyroid transcription factor-1)
There are three histological types of malignant mesothelioma: (1) Epithelioid; (2) Sarcomatoid; and (3) Biphasic (Mixed). Epithelioid comprises about 50-60% of malignant mesothelioma cases and generally holds a better prognosis than the Sarcomatoid or Biphasic subtypes.[27]

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