Immunohistochemical studies play an important role for the pathologist in differentiating malignant mesothelioma from neoplastic mimics. There are numerous tests and panels available. No single test is perfect for distinguishing mesothelioma from carcinoma or even benign versus malignant. Currently, there is no FDA approved immunohistochemistry assay for the diagnosis of mesothelioma so different cancer centers use different panels.
|EMA (epithelial membrane antigen) in a membranous distribution||CEA (carcinoembryonic antigen)|
|WT1 (Wilms' tumour 1)||B72.3|
|HBME-1 (human mesothelial cell 1)||TTF-1 (thyroid transcription factor-1)|